Update on the genetics of primary open-angle glaucoma
نویسندگان
چکیده
منابع مشابه
The genetics of primary open angle glaucoma.
The advent of the discipline of molecular genetics over the past decade has led to a dramatic growth in our understanding of the genetics of a myriad of diseases. Ophthalmology has benefited greatly from this new technology, with significant advances in our knowledge about conditions as varied as aniridia and retinitis pigmentosa. 2 Our understanding of the genetics of primary open angle glauco...
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Primary open-angle glaucoma (POAG) is an idiopathic disorder in which the resistance to outflow through the trabecular meshwork gradually increases and the intraocular pressure (IOP) rises, causing irreversible damage to the optic nerve POAG is the second most common cause of vision loss in the U.S. Usually asymptomatic until advanced visual field loss has occurred; less than 50% of those...
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There are 3 elements which contribute to the development of the human eye in the primitive embryo: the surface ectoderm, the neuroectoderm, and the neural crest which has been recognized as a potential source of mesenchymal tissue. The meso-dermal contribution is limited to the formation of extra ocular muscles and blood vessels endothelium [1]. The vertebrate neural crest not only gives rise t...
متن کاملprimary open-angle glaucoma risk factors
purpose: the objective of this study was to identify possible risk factors associated with primary open-angle glaucoma (poag). methods: a case-control study included patients seen at rasoul-akram hospital ophthalmology clinic. cases were consecutive patients with confirmed unilateral or bilateral poag presented during the study period. controls were a random sample of all other patients aged 30...
متن کاملAn Updated Review on the Genetics of Primary Open Angle Glaucoma
Epidemiological studies suggest that by 2020 the prevalence of primary open angle glaucoma (POAG) is estimated to increase to 76.0 million, and to 111.8 million by 2040 globally due to the population aging. The prevalence of POAG is the highest among those of African descent, followed by Asians, and the lowest in Europeans. POAG is a genetically complex trait with a substantial fraction exhibit...
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ژورنال
عنوان ژورنال: Experimental Eye Research
سال: 2019
ISSN: 0014-4835
DOI: 10.1016/j.exer.2019.107795